Gynostemma pentaphyllum usually has 5-7 leaflets, which are oval or lanceolate. The petiole is 3-7cm long, with dark green on the top and light green on the back. The leaves of Apocynum are elliptic lanceolate to oval oblong, petioles are shorter than the former, about 3-6 mm long.
Gynostemma pentaphyllum is panicle, corolla color is light green or white, there are 5 deep cracks, lobes are ovate lanceolate. While Apocynum for the panicle cyme, corolla color for purplish red or pink, cylindrical bell, lobes for oval oblong.
The seeds of Gynostemma pentaphyllum are ovate and heart-shaped, and the color is grayish brown or dark brown. The seed of Apocynum venetum is oval and oblong, and its color is yellowish brown.